Glutathione Multiple Functions

Glutathione Augmentation
As Immune System Strategy!

Glutathione Multiple Functions! ...Glutathione augmentation is a strategy developed to address states of glutathione deficiency, high oxidative stress, immune deficiency, and xenobiotic overload in which glutathione plays a part in the detoxification of the xenobiotic in question.

Many clinical pathologies are associated with glutathione deficiency and oxidative stress and are elaborated upon in numerous medical references.

Low glutathione is also strongly implicated in wasting and negative nitrogen balance seen in muscle wasting.

Glutathione has multiple functions! ...The Technical Stuff!

1. It is the major endogenous antioxidant produced by the cells, participating directly in the neutralization of free radicals and reactive oxygen compounds, as well as the maintenance of exogenous antioxidants such as vitamins C and E in their reduced (active) forms.

2. Through direct conjugation, it detoxifies many xenobiotics (foreign compounds) and carcinogens, both organic and inorganic such as heavy metals, aromatic hydrocarbons, nitrosamines, benzopirines and others including pharmacological agents such as acetaminophen.

3. It is essential for the immune system to exert its full potential, e.g.

(1) modulating antigen presentation to lymphocytes, thereby influencing cytokine production and the type of response (cellular or humoral) that develops,

(2) enhancing proliferation of lymphocytes thereby increasing magnitude of response,

(3) enhancing killing activity of cytotoxic T cells and NK cells, and...

(4) regulating apoptosis, thereby maintaining control of the immune response.

4. It plays a fundamental role in numerous metabolic and biochemical reactions such as DNA synthesis and repair, protein synthesis, prostaglandin synthesis, amino acid transport and enzyme activation.

Many systems in the body are adversely affected by low glutathione levels, including the immune system, the nervous system, the gastrointestinal system and the cardiovascular-pulmonary system.

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